1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 9
1.2 List of Figures 13
2 Introduction 14
2.1 Pain Management Overview 14
3 Products under Development 15
3.1 Pain Management – Pipeline Products by Stage of Development 15
3.2 Pain Management – Pipeline Products by Territory 16
3.3 Pain Management – Pipeline Products by Regulatory Path 17
3.4 Pain Management – Pipeline Products by Estimated Approval Date 18
3.5 Pain Management – Ongoing Clinical Trials 19
4 Pain Management – Pipeline Products under Development by Companies 20
4.1 Pain Management Companies – Pipeline Products by Stage of Development 20
4.2 Pain Management – Pipeline Products by Stage of Development 22
5 Pain Management Companies and Product Overview 24
5.1 Advanced Amputee Solutions, LLC Company Overview 24
5.2 Algodyne Ltd Company Overview 25
5.3 Algometron Pty Ltd Company Overview 26
5.4 Aptima, Inc. Company Overview 27
5.5 Avacen Inc. Company Overview 28
5.6 AxioMedic Inc Company Overview 29
5.7 BioElectronics Corp Company Overview 30
5.8 Blacktown NC LLC Company Overview 33
5.9 Cerimon Pharmaceuticals, Inc. (Inactive) Company Overview 34
5.10 CoolSense Medical Ltd. Company Overview 35
5.11 Diavibe, Inc. Company Overview 36
5.12 Easytech Srl Company Overview 37
5.13 EP Global Communications, Inc. Company Overview 38
5.14 GRoK Technologies LLC Company Overview 40
5.15 Hadassah Medical Center Company Overview 41
5.16 Headway Company Overview 42
5.17 IMEXCO General Ltd. Company Overview 44
5.18 Immuno-Genic Corporation Company Overview 45
5.19 Intralink-Spine LLC Company Overview 46
5.20 Intronix Technologies Corporation Company Overview 47
5.21 Kalaco Scientific, Inc. Company Overview 48
5.22 Lasmed, LLC Company Overview 49
5.23 Magzor Corporation Company Overview 50
5.24 Mathematical Bio-Solutions Inc. Company Overview 51
5.25 Medasense Biometrics Ltd Company Overview 52
5.26 Meddynamics Ltd. Company Overview 54
5.27 Medovex Corporation Company Overview 55
5.28 Myelyx Medical Company Overview 57
5.29 NeoMedLight Company Overview 58
5.30 NeuroMetrix Inc Company Overview 59
5.31 Neurospectrum LLC Company Overview 62
5.32 Omron Healthcare Co Ltd Company Overview 63
5.33 Orthovative Technologies Company Overview 64
5.34 Sea Run Holdings Inc Company Overview 65
5.35 Stanford University Company Overview 66
5.36 Tecnalia Corporacion Tecnologica Company Overview 68
5.37 Teijin Pharma Ltd Company Overview 69
5.38 Tyndall National Institute Company Overview 70
5.39 University of California San Diego Company Overview 71
5.40 University of Limerick Company Overview 72
5.41 University of Rochester Company Overview 73
5.42 University of Texas Medical Branch at Galveston Company Overview 74
5.43 University of Washington Company Overview 75
5.44 VascuActive Ltd Company Overview 76
5.45 Vertech Inc Company Overview 77
5.46 West Virginia University Company Overview 78
6 Pain Management- Recent Developments 79
6.1 Nov 29, 2016: NeuroMetrix Receives CE Mark Certification for Quell Wearable Pain Relief Device 79
6.2 Nov 23, 2016: Zynex to Raise USD1.5 Million in Private Placement 79
6.3 Nov 16, 2016: NeuroMetrix’ Quell Device Makes Second Appearance at American Society of Regional Anesthesia’s Annual Pain Medicine Meeting 79
6.4 Nov 15, 2016: NanoVibronix Provides Third Quarter 2016 Business Update 80
6.5 Nov 15, 2016: Cynosure Health Welcomes Three New Board Members 81
6.6 Nov 14, 2016: DJO Global Announces Appointment of Brady Shirley as President and Chief Executive Officer 81
6.7 Nov 14, 2016: Acura Pharmaceuticals Announces Third Quarter 2016 Financial Results 82
6.8 Nov 14, 2016: Dynatronics Announces 10% increase in Top Line Sales for Fiscal 2017 First Quarter 82
6.9 Nov 10, 2016: NeuroMetrix Chief Commercial Officer Frank McGillin to Present Quell Wearable Pain Relief Technology at 16th Annual Diabetes Technology Meeting 83
6.10 Nov 10, 2016: Zynex Announces Third Quarter 2016 Profit 84
6.11 Nov 09, 2016: Syneron Medical Reports Third Quarter 2016 Revenue of $71.5 Million 84
6.12 Nov 08, 2016: NeuroMetrix Announces Promotion of Frank McGillin to Chief Commercial Officer 85
6.13 Nov 08, 2016: DJO Global Announces Financial Results for Third Quarter 86
6.14 Nov 07, 2016: Theralase Technologies Raises USD3.2 Million in Public Offering of Units 87
6.15 Nov 07, 2016: Aralez Reports Third Quarter 2016 Financial Results 87
6.16 Nov 07, 2016: Nevro Reports Third Quarter 2016 Financial Results 89
6.17 Nov 03, 2016: Medovex Conducts Successful Cadaver Lab at NASS 2016 90
6.18 Nov 03, 2016: Cara Therapeutics Reports Third Quarter 2016 Financial Results 91
6.19 Nov 02, 2016: Medovex Announces Successful Largest Living Tissue Population Test to Date 92
6.20 Nov 01, 2016: Cynosure Promotes Doug Delaney to Chief Commercial Officer 93
6.21 Oct 28, 2016: Sanofi Announces Strong Q3 2016 Results 93
6.22 Oct 27, 2016: NeuroMetrix Announces Issuance Of New U.S. Patent For Quell Wearable Pain Relief Technology 100
6.23 Oct 26, 2016: Boston Scientific Announces Results For Third Quarter 2016 100
6.24 Oct 26, 2016: Bovie Medical Reports 2016 Third Quarter and Nine Month Results 101
6.25 Oct 25, 2016: Cynosure Announces Record Third-Quarter Revenues; Revenues Increase 36 Percent from Prior Year to $106.4 Million 103
6.26 Oct 20, 2016: NanoVibronix Expands Senior Management Team and Board of Directors 104
6.27 Oct 20, 2016: NeuroMetrix Reports Q3 2016 Financial Results 105
6.28 Oct 20, 2016: ICON Announces Executive Leadership Transition 106
6.29 Oct 20, 2016: ICON Reports Third Quarter 2016 Results 106
6.30 Oct 17, 2016: Syneron Medical Strengthens Senior Management Team 107
6.31 Oct 17, 2016: Syneron Medical Announces Preliminary Third Quarter 2016 Revenue 108
6.32 Oct 13, 2016: Medovex Reports Successful Demonstration of Expanding EMEA Business at EuroSpine 2016, Berlin, Germany 109
6.33 Oct 13, 2016: AVACEN Medical Announces Support for New ClinicalTrials.gov Initiative 109
6.34 Oct 11, 2016: U.S. Special Forces Begins Testing Of Oska Wellness Pulsed Electromagnetic Field Device For Use In Pain Management 110
6.35 Oct 11, 2016: Relievant MedSystems Raises USD36 Million in Equity Financing 111
6.36 Oct 10, 2016: NeuroMetrix Announces Participation in Discover Blue: New York City Bluetooth Event 111
6.37 Oct 10, 2016: BioElectronics Comments on its U.S. FDA’s OTC Market Clearance Application 111
6.38 Oct 10, 2016: Professor Ian Meredith To Join Boston Scientific As Executive Vice President And Global Chief Medical Officer 112
6.39 Oct 06, 2016: Zygood Raises USD0.2 Million in Venture Financing 112
6.40 Oct 05, 2016: NeuroMetrix to Sponsor Study Assessing the Impact of Quell Technology on Chronic Low Back Pain 112
6.41 Oct 05, 2016: HYPERICE Introduces VENOM, a Wearable Back Device That Harnesses the Power of Heat and Vibration for Maximum Warm Up and Recovery 113
6.42 Oct 04, 2016: Relaxis Pad for Restless Legs Syndrome Helps Patients Avoid General Anesthesia 113
6.43 Oct 03, 2016: BioElectronics ActiPatch Drug-free Pain Therapy to be Featured at Pharmacy Week in Trinidad & Tobago W.I. 114
6.44 Sep 30, 2016: Dynatronics Welcomes David A. Wirthlin as Its New Chief Financial Officer 115
6.45 Sep 30, 2016: Sanofi Appoints Alan Main to Executive Committee and Executive Vice President, Consumer Healthcare 115
6.46 Sep 28, 2016: BioElectronics Submits Back Pain Relief & Medication Use Side Effects Registry Study for Publication 116
6.47 Sep 28, 2016: NanoVibronix Announces Distribution Agreement With Mano Equestrian Services (PTE) LTD in Singapore for Equine PainShield 116
6.48 Sep 26, 2016: Dynatronics Announces Fourth Quarter and Fiscal Year 2016 Financial Results 116
6.49 Sep 22, 2016: NeuroMetrix Announces Quell Fibromyalgia Pilot with Synovation Medical Group 117
6.50 Sep 20, 2016: Professional athletic trainers adopt sam Sport to accelerate injury recovery and reduce opioid use for pain management 118
6.51 Sep 20, 2016: NeuroMetrix Reports Progress on Quell Availability within the Veterans Health Administration 119
6.52 Sep 14, 2016: Medovex Enters Into International Distribution Agreement With M.Fast Technologies 119
6.53 Sep 13, 2016: BioElectronics Launches ActiPatch, Musculoskeletal Pain Therapy In Sweden 120
6.54 Sep 13, 2016: Cynosure to Name Stephen J. Webber as New Chief Financial Officer 120
6.55 Sep 13, 2016: Zynex Announces August Orders 121
6.56 Sep 08, 2016: NeuroMetrix Announces Quell Dispensing Partnership with Comprehensive Pain Specialists 121
6.57 Sep 07, 2016: Sanofi Appoints New Research Head for Immunology and Inflammation 121
6.58 Sep 06, 2016: DJO Global Announces Appointment of Mike Eklund as Chief Operating Officer and Chief Financial Officer 122
6.59 Sep 06, 2016: Sanofi Board Of Directors Provides Update 122
6.60 Sep 05, 2016: Teijin Publishes Integrated Report 2016 123
6.61 Aug 30, 2016: SANUWAVE Health Reports Record Year to Date Order Book for orthoPACE and dermaPACE – Up 280% Over 2015 123
6.62 Aug 29, 2016: TetraGenetics Enters into Partnership with Pharmaceutical Company 124
6.63 Aug 26, 2016: Relievant MedSystems Raises USD22.2 Million in Venture Financing 124
6.64 Aug 25, 2016: NeuroMetrix Announces That Quell Will Be Featured in the Target Open House 124
6.65 Aug 25, 2016: Medovex Adds 35 Year Orthopedic Industry Veteran Ron Lawson to Board of Directors 124
6.66 Aug 24, 2016: Medovex Begins Commercial Production of DenerveX Pro-40 Generator in Preparation for EU Launch 125
6.67 Aug 24, 2016: Acrux: Financial Report for the year ended 30 June 2016 126
6.68 Aug 23, 2016: Pyng Medical Reports Third Quarter Fiscal 2016 Results 127
6.69 Aug 22, 2016: Zynex Announces Second Quarter 2016 Results 127
6.70 Aug 16, 2016: NeuroMetrix Commentary on Strategic and Business Partnerships for Quell Wearable Pain Relief Technology 128
6.71 Aug 16, 2016: Zynex Announces July Orders 129
6.72 Aug 15, 2016: SANUWAVE Health Reports Second Quarter Financial Results and Provides a Business Update 129
6.73 Aug 09, 2016: Aralez Reports Second Quarter 2016 Financial Results 130
6.74 Aug 08, 2016: Acura Pharmaceuticals Announces Second Quarter 2016 Financial Results 132
6.75 Aug 08, 2016: Nevro Reports Second Quarter 2016 Financial Results 132
6.76 Aug 05, 2016: Medovex Raises USD1.2 Million in Private Placement of Units 133
6.77 Aug 04, 2016: Syneron Medical Reports Second Quarter 2016 Revenue of $75.0 Million and Non-GAAP EPS of $0.09 133
6.78 Aug 04, 2016: Cara Therapeutics Reports Second Quarter 2016 Financial Results 135
6.79 Aug 03, 2016: NeuroMetrix To Present Quell Wearable Pain Technology at National Association of Chain Drug Stores Total Store Expo 136
6.80 Aug 02, 2016: NeuroMetrix Reports that the Quell Health Cloud Has Collected Over 1 Million Hours of Quell Therapy and Health Data 136
6.81 Aug 01, 2016: Bovie Medical Reports Second Quarter and First Half 2016 Results 137
7 Appendix 218
7.1 Methodology 218
7.2 About GlobalData 220
7.3 Contact Us 220
7.4 Disclaimer 221